Royal Air Force Typhoon jets have joined forces with France's air force in a combined operation against an subterranean weapons facility in Syrian territory used by the Islamic State group (IS), per a report from the UK's MoD.
The site, identified by reconnaissance, was assessed as containing munitions and bombs, the statement said, and was positioned in mountains just to the north of Palmyra in the heart of Syria.
"Our fighter planes utilized laser-guided Paveway IV weapons to strike a series of entry passages leading to the depot... early reports suggest the target was engaged successfully," the MoD said.
There was no evidence of any civilian casualties in the strike on Saturday evening and each participating jet returned safely, the ministry further stated.
The Typhoon FGR4s were supported by a Voyager refuelling tanker.
The Islamic State group - also known as the so-called Islamic State - established militant control over large swathes of both Syria and Iraq before its territorial defeat in 2019.
"This operation demonstrates our UK leadership, and determination to stand shoulder to shoulder with our partners, to stamp out any resurgence of IS and their dangerous and violent ideologies in the region," UK Defence Secretary the minister said.
UK warplanes have carried out overwatch operations over Syrian airspace to "prevent any efforts to regroup" of IS after its routing at the climactic battle in Baghuz in 2019, the MoD reported.
"I want to thank every member of our armed forces participating in this operation for their expertise and their courage," he added. "They were part of a great many British personnel deployed over Christmas and New Year. This mission, to eliminate dangerous terrorists who threaten our way of life, demonstrates how British military are prepared to act, all year round, ensuring Britain's security at home and powerful internationally."
During December, the US military carried out what it termed a "large-scale strike" on IS targets in the country, following an assault claimed the lives of two US troops and a civilian linguist in Palmyra.
The United Nations says Islamic State still maintains between 5,000 and 7,000 fighters in Iraq and Syria.